SWOPT coordinator, Andre C. Stiel, and Elsa C. Rodrigues have published a new review in FEBS Letters: “It’s a two-way street: Photoswitching and reversible changes of the protein matrix in photoswitchable fluorescent proteins and bacteriophytochromes“.
The authors review the interactions between chromophore and protein matrix, focusing on photoswitching fluorescent proteins (from the GFP family) and natively photoswitching bacteriophytochromes. They provide an in-depth discussion on how the bidirectional interplay between photoswitching photophysics and the protein matrix has been exploited for the development of optogenetic and imaging tools.
Rodrigues, E.C. and Stiel, A.C. (2023), It’s a two-way street: Photoswitching and reversible changes of the protein matrix in photoswitchable fluorescent proteins and bacteriophytochromes. FEBS Lett, 597: 1319-1344. https://doi.org/10.1002/1873-3468.14609